The Contribution of Activated Factor XIII to Fibrinolytic Resistance in Experimental Pulmonary Embolism

The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism.

BACKGROUND The resistance of thrombi to fibrinolysis induced by plasminogen activators remains a major impediment to the successful treatment of thrombotic diseases. This study examines the contribution of activated factor XIII (factor XIIIa) to fibrinolytic resistance in experimental pulmonary embolism. METHODS AND RESULTS The fibrinolytic effects of specific inhibitors of factor XIIIa-media...

Factor XIII and fibrinolytic resistance.

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Catalytic life of activated factor XIII in thrombi. Implications for fibrinolytic resistance and thrombus aging.

BACKGROUND Because the increased fibrinolytic resistance of older thrombi may be caused by the continuous cross-linking action of fibrin-bound activated factor XIII (FXIIIa), we examined the persistence of FXIIIa catalytic activity in clots of various ages. METHODS AND RESULTS The time-related changes in FXIIIa activity in clots was measured with (1) alpha(2)-antiplasmin (alpha(2)AP), a physi...

contribution of setting to the study of characters and the main idea in e. brontes: wuthering heights and t. hardys: return of the native.

this thesis aims to adduce an unmitigated and comprehensive explication concerning the relationship of three significant elements of fiction: setting, chracter and theme. my research is basically placed on two outstanding novels of the 19th century: emily brontes wuthering heights and thomas hardys return of the native. my endeavour lies in studying the correlation among the three above-mention...

Treatment of experimental pulmonary embolism by main pulmonary arterial infusion of a fibrinolytic agent.